Sentence examples for by ectopic activation of from inspiring English sources

In addition, the JAK/STAT pathway has a unique function in the differentiation of progenitors, which is not rescued by ectopic activation of the EGFR pathway.

In addition, excess growth signaling by ectopic activation of Tor signaling in wild-type larvae, was not sufficient to induce precocious autophagy.

Consistent with this, olig2 is overexpressed by ectopic activation of Hh (dnPKA injected), while its expression is largely reduced in gli2a ty119 homozygous embryos (Fig. 6E G).

Consistent with this, Hand2 expression also extended anteriorly probably due to inhibition of Gli3 repressor formation by ectopic activation of Shh signalling (as revealed by the extended Ptch1 expression).

The hitchhiker mutants exhibit preaxial polydactyly, and we hypothesized that this might be caused by ectopic activation of the Shh pathway, similar to that observed in the neural tube.

Whereas the LATE model predicts that there should be no effect from ectopic serotonin on either side, the EARLY model predicts that excess serotonin signaling, especially on the left side, will randomize the LR axis by ectopic activation of intracellular receptors (Carneiro et al., 2011).

This Dmp53-mediated non-autonomous growth delay strikingly contrasts with the results from the previous AiP studies where Dmp53 and caspases promote long-range, non-autonomous proliferation when apoptosis is induced by IR or by the ectopic activation of Rpr or Hid.

The mild phenotype displayed by dpn mutant cells in the wing disc when compared to the Notch or the Su(H) mutant cells (Schweisguth and Posakony, 1992; de Celis and García-Bellido, 1994) and the partial rescue of the phenotypes produced by the ectopic activation of Notch signalling by dpn alleles, suggests the existence of additional Notch signalling targets.

In contrast, the ectopic expression of dpn in the presumptive wing blade (UAS-dpn/nub-Gal4) prevented the differentiation of veins (Fig. 2C), a phenotype also caused by the ectopic activation of Notch signalling.

These results suggest that the preaxial polydactyly typically observed in the Mks1 mutant results from a relative decrease in Gli3R level in the anterior limb bud brought on by the ectopic activation of Shh.

In the embryo, the upregulation of Abd-B expression in PS11 would require either an increase in Abd-B promoter activity or the ectopic activation of iab-7 by the iab-6 initiator in PS11 cells.