Sentence examples for by early changes in from inspiring English sources

Consequently, our results suggest that the increased mortality seen with HES in the 6S trial was not mediated by early changes in systemic inflammation.

In the past several years, researchers have noted that cancers linked to chronic inflammation, such as some colon tumors, appear to be enabled by early changes in patterns of DNA methylation, the addition of a molecule known as a methyl group to the "engine-starter" region of a gene known as a promoter.

This response was accompanied by early changes in phospholipid and glucose metabolism, reflecting the long-term tumor growth delay caused by PI3K inhibition in this model.

General clinical symptoms are defined by early changes in personality and cognitive functions, followed by typical involuntary choreatic movements; advanced stages of the disease include bradykinesia, rigidity, and dementia.

Pharmacogenomics being in use to a limited degree, such multidisciplinary research can lead to evidence-based results, impacting optimal promotive/preventive/curative healthcare management by early changes in lifestyle, avoiding or lessening severity of diseases, and decreasing cost and risk of clinical trials by targeting persons capable of responding to a drug.

Predictability analyses by early changes in DAS28 ESR), SJC and CDAI were conducted using observed data (from the OL set); data for DAS28 ESR) were also analyzed using LOCF-imputed data from the full analysis set (FAS) (comprising all patients who received ≥1 dose of CZP).

In terms of mechanisms by which early changes in catastrophizing shape later changes in pain, some prior reports highlight compliance and willingness to engage in physical activity.

Women failed to recognise their behaviours as an ED by normalising early changes in eating and mood and discarding an ED as a 'too severe' diagnosis.

The value of monitoring this area of the peripheral circulation is demonstrated by the fact that early changes in the sublingual microcirculatory flow are a sensitive and specific predictor of poor outcome in septic critically ill patients (Sakr et al. 2004; Trzeciak and Rivers 2005).

The initiation phase of HSC activation starts by paracrine signals, which include early changes in ECM composition as a result of increased fibronectin secretion by liver sinusoidal endothelial cells, which leads to mild gene expression changes that render HSCs more cytokine sensitive.

These results suggest that changes in cartilage matrix turnover detected by molecular biomarkers may reflect early changes in cartilage structure that account directly or indirectly for knee pain.