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Suddenly the realm of mental disorder, which is supposed to be delineated, as the introduction to the D.S.M. puts it, by "dysfunction in the individual," is being distorted by the role of others.
This has opened the possibility of Kv7 channels as a target for treatment of diseases characterized by dysfunction in the dopaminergic system, such as ADHD, drug abuse, and schizophrenia [15].
This is further exacerbated by dysfunction in the lipoprotein secretion pathway.
DOI: http://dx.doi.org/10.7554/eLife.02196.004 Schizophrenia is characterized by dysfunction in the prefrontal cortex (Arnsten et al., 2012), where Aph1bc is highly expressed (Dejaegere et al., 2008).
In a previous clinical trial, we found that the development of pancreatic cancer was closely correlated with tumor immune escape, mediated by dysfunction in the circulating NK cells [ 28].
Impaired postural stability may be caused by dysfunction in the integration of each of the four sensory systems: visual [ 2, 3], proprioceptor [ 4, 5], exteroceptor [ 6], and vestibular [ 7, 8].
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This class of agent is in line with the cholinergic hypothesis (Francis et al., 1999), stating that Alzheimer's disease could be caused by dysfunctions in the processing of the acetylcholine.
The presence of pain in the masticatory system, especially related to myogenic TMD, could be caused by dysfunctions in the cervical column, or vice versa, showing the intrinsic relationship between the different structures [ 1, 5].
The results demonstrate a causal relationship between the dynamics of GABA release and the generation of tonic inhibition, and identify a novel mechanism of epileptogenesis generated by dysfunctions in the dynamics of release that can be effectively targeted by novel antiepileptic strategies.
Thus, the attenuation of DAMGO-induced antinociception in streptozotocin-induced diabetic mice is probably caused by dysfunction in cellular pathways after the activation of G-proteins.
The high overall mortality rate observed is caused by dysfunction in other organs.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com