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After mitochondria depolarization, stabilized PINK1 phosphorylates Parkin at Ser65 in the UBL domain to activate Parkin by driving conformational changes (Shiba-Fukushima et al., 2012).
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However, the detailed interactions driving conformational changes seem different, as e.g. the switches identified by Williams et al., and the charge pairs that they observe as important are not conserved.
A free energy of 9 12 kcal/mol becomes available upon glutamate binding for driving conformational changes in S1S2 associated with receptor activation.
Of importance, different agonists are in principle capable of driving different conformational changes in the receptor to result in selective interactions with different downstream 'effectors'effectors
To effectively release the structural constraints that stabilize the inactive rhodopsin state, photon energy is absorbed and used for retinal isomerization (cf. section 2), driving subsequent protein conformational changes.
Chair-chair interconversion is a complicated process brought about by successive conformational changes within the molecule.
Biomolecular associations often accompanied by large conformational changes, sometimes folding and unfolding.
transmission of the stimulus by inducing conformational changes of the receptor iii.
This raises a basic question: Does molecular recognition gain any advantage by such conformational changes?
Pin1 is a prolyl isomerase that regulates protein function by accelerating conformational changes.
It is also influenced by the conformational changes resulted from the ionization of other amino acids.
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