Sentence examples for by downregulation of expression from inspiring English sources

Thus, the role of hUCBSC in preventing cancer cell proliferation at the cellular level is evidenced by downregulation of expression of cyclin D1.

Macrophages clearly responded to the tested compound by downregulation of expression of proinflammatory cytokines.

Therefore, we can speculate that this upregulation followed by downregulation of expression may be induced by a negative feedback mechanism involving miRNA generation.

Loss of function of Chk2, by downregulation of expression and p53 by mutation, has been reported in a proportion of sporadic breast cancers (Sullivan et al, 2002).

First, Hog1-mediated G1 arrest is partially mediated by downregulation of expression of the G1 cyclins Cln1,2 and of the S-cyclin Clb5 (Bellí et al. 2001).

We used quantitative RT-PCR (qRT-PCR) to investigate whether the defect in microneme formation in the Δ shlp1 ookinete is accompanied by downregulation of expression of genes encoding ookinete micronemal proteins in activated gametocytes and ookinetes.

Regardless, our data provide strong evidence that cabozantinib-mediated downregulation of c-Met expression followed by downregulation of SOX2 expression may be key factors in overcoming resistance toward gemcitabine and in avoiding development of prounounced extrinsic resistance after repeated therapy cycles of cabozantinib.

Notably, an ET-axis expression pattern similar to that of breast cancer was recently found in cervical cancer; that is, upregulation of EDN1, EDN2, EDNRA and EDNRB expression was accompanied by downregulation of EDN3 expression in cancerous cervix as compared with normal cervical epithelium [ 46].

Interestingly, followed by downregulation of eGFP expression in ORF1, the decrease of mCherry expression in ORF2 was also observed.

The absence and downregulation of CRBN expression in human myeloma cell lines result in IMiDs resistance, which is also supported by downregulation of CRBN expression at the time of lenalidomide resistance in MM patients [ 5].

Forced expression of miR-328 resulted in cardiomyocyte hypertrophy in cultured neonatal rat ventricular cells, which was accompanied by downregulation of SERCA2a expression and activation of the calcineurin/NFATc3 signaling pathway.