Sentence examples for by downregulating its expression from inspiring English sources
The antitoxin inhibits the toxin by downregulating its expression.
Thus, in addition to inhibit YAP function by phosphorylation of YAP and promoting YAP nuclear exit, Mst1/2-Lats signaling can also inhibit YAP function by downregulating its expression level [ 41].
This suggests that basiliximab prevented binding of the anti-CD25 staining antibody by occupying CD25 or downregulating its expression [11], but that it did not lead to significant Treg depletion.
Our group has recently demonstrated that the NKG2D-activating receptor is regulated by histone acetylation (H3K9Ac) and that inhibition of histone acetyltransferase (HAT) activity by curcumin not only downregulates its expression at the cell surface but also leads to a marked reduction in the lytic capacity of NK cells.
The use of NCCM downregulated its expression by more than 50%, suggesting that factors in NCCM, in part, inhibit the inflammatory aspect of disc degeneration.
To confirm the role of PGC-1 α in coordinating mitochondrial turnover, we downregulated its expression by means of siRNA transfection.
These results demonstrate that miR-125b and miR-181a/b are induced during ESC differentiation and contribute to this process by downregulating Cbx7 expression through direct targeting of its 3′UTR.
A recent study described that the miR-675 is exclusively expressed in the placenta during development, where it controls growth probably by downregulating the expression of Igf1r[ 2].
It is generally accepted that miRNAs exert their function by downregulating the expression of their downstream target genes.
Finally, we found that decreased expression of lncRNA HNF1A-AS1 suppressed the Wnt/β-catenin signaling pathway activity by downregulating the expression of β-catenin,cyclinD1, and c-myc.
Moreover, both micropatterned and aligned nanofibrillar substrates promoted an athero-resistant EC phenotype by reducing endothelial adhesiveness for monocytes and platelets, as well as by downregulating the expression of adhesion proteins and chemokines.
