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"There is no way you can get around that except by doing a randomized controlled trial," in which women are randomly assigned to take, or not take, the drugs.
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'Because you need to find out whether these things work, and the only way of finding out if they work is by trialing it, or doing a randomized trial.
Dr. Bonow said it would still be a good idea to do a randomized controlled study.
When he retired from rowing last July, he decided to do a randomized, blinded, placebo-controlled experiment on himself.
Nevertheless, Dr. Dwork said, "This is an interesting study and it's important to do this kind of work, especially because you're in a situation where it's difficult or impossible to do a randomized, double-blind study".
Researchers have been reluctant to do a randomized breast-feeding study because of concerns about the ethics of withholding a treatment or practice that is widely thought to be beneficial, like breast-feeding.
The researchers did a randomized, blinded, crossover study using the most rigorous research design to ward off any criticism (which will inevitably come from the $1 trillion food industry).
But in the U.S. it would be very, very difficult" to do a new randomized mammography trial.
Along with colleagues, I did a large, randomized experiment comparing these strategies.
The only way to firmly prove positive vitamin D effects is by doing the properly designed randomized controlled trials (RCTs).
"We didn't experimentally expose people to marijuana, which you would do in a randomized trial….
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com