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Progression from the non-neuronal pluripotent stem cell to a restricted neural lineage is characterized by distinct patterns of gene expression, particularly the restriction of neuronal gene expression to neurons.
In the confined space of the medial entorhinal cortex, the Mosers found, maps of varying scales and levels of complexity could be represented and encoded by distinct patterns of cellular firing.
Multiple resting state networks have now been identified [13] and are characterised by distinct patterns of resting connectivity across different regions [14].
Recent evidence has suggested that this heterogeneity is underpinned by distinct patterns of genomic aberrations, which may contribute to the different transcriptomic profiles and clinical phenotypes [ 1- 4].
We conclude that the distinct arousal states are characterized by distinct patterns of coherence changes within that same network of brain regions.
Muscheck et al. [ 26] reached the same conclusion, and showed that different histologic subgroups of bladder tumors are characterized by distinct patterns of chromosomal alterations.
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This proposal is supported by the distinct patterns of 8HQ substitution determined to be important for JmjC-domain demethylase activity here (Figure 3) and the recent study of Smirnova et al. where a branched substituent at the 7-position was found to be important for 8HQ activity against the related PHDs.
The middle panel shows the cell cycle of wild type retinal stem cells and the putative role of the YAP/PKNOX1 complex in the control of S-phase temporal progression (represented by the distinct patterns of DNA replication foci).
Recently, Sorlie and coworkers have confirmed their results in an independent set of breast tumors, refining previously defined sub-types of breast tumors that could be distinguished by their distinct patterns of gene expression [ 4].
The pathway activities of hypoxia, lactic acidosis, acidosis and glucose deprivation were investigated in a collection of 1,143 breast tumors, which have been separated into 17 breast tumor subgroups defined by their distinct patterns of oncogenic pathways.
The major mechanisms controlling sex differences in liver gene expression have been well-characterized [ 52] and are dictated by the distinct patterns of continuous vs. pulsatile plasma growth hormone (GH) secretion in females and males, respectively [ 53].
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