Sentence examples for by direct suppression of from inspiring English sources

It has been reported that treatment with a combination of anticancer drugs (5-fluorouracil) and triterpenes (betulinic acid, ursolic acid and oleanolic acid) resulted in additive or synergistic suppression of cell growth in vitro and in the reduction of experimental esophageal squamous carcinoma cells cell metastasis by direct suppression of cell growth in vivo (Yamai et al. 2009).

By direct suppression of mitogen-activated protein kinase/extracellular signaling-regulated kinase1/2 (MAPK/Erk1/2) signaling pathway in NSCs using U0126, known to inhibit the activation of Erk1/2, we demonstrated that the enhancement of Erk1/2 pathway is one of the effects of H-UNCD-induced NSCs differentiation.

These data indicate that FHL1C regulates T-ALL progression by direct suppression of Notch1 target gene expression.

Therefore, IL-6 might contribute to the resolution of acute and chronic inflammatory processes by direct suppression of IL-1β and TNF-α [ 35].

They function at multiple levels to shape the innate immune response and maintain homeostasis by direct suppression of the expression of their target proteins, preferentially crucial signaling components and transcription factors.

In summary, treatment with a combination of VCR and BA resulted in synergistic suppression of cell growth in vitro and in the prevention of B16F10 melanoma experimental metastasis by direct suppression of cell growth in vivo.

Conversely, PPAR-γ while a potent activator of adipogenesis also strongly inhibits osteogenesis [64], [65] by both direct suppression of RUNX2 expression and by altering the potential of RUNX2 to activate downstream osteogenic products [66], [67].

By showing the direct suppression of PTC growth and dome formation treated with heparinase, we demonstrated that the interaction between cell surface heparin sulfate proteoglycan and chitosan played an important role in PTC proliferation and differentiation.

Given the inherent redox sensitivity of T cells, we tested the hypothesis that oxidants may mediate the direct suppression of Teffs by Tregs.

16 These results led to the conclusion that CLL-related anemia is not an expression of an intrinsic defect of erythroid precursors, but the result of direct suppression of erythropoiesis by TNF-α. Figure 1 shows the pathway for differentiation of erythroid progenitors into mature red blood cells.

The expression and activation of IDO creates a tolerogenic milieu in the tumor and the tumor-draining lymph nodes (LN) either via direct suppression of T cells by degradation of the essential amino acid tryptophan or via enhancement of local regulatory T-cell (Treg) -mediated immunosuppression.