Sentence examples for by direct reprogramming of from inspiring English sources

Induced pluripotent stem cells (iPSCs) are generated by direct reprogramming of somatic cells and hold great promise for novel therapies.

This can occur by direct reprogramming of target cell metabolism21 or by competition for fuels in the tumour microenvironment (TME) leading to starvation or adaptions to metabolic stress22.

Induced pluripotent stem cells are generated by direct reprogramming of adult liver and stomach cells.

In summary, we report here a new strategy to obtain integration-free functional porcine neural progenitor cells by direct reprogramming of porcine fetal fibroblasts in vitro.

These data suggest that iPS cells are generated by direct reprogramming of lineage-committed somatic cells and that retroviral integration into specific sites is not required.

Different strategies for the production of cardiomyocytes from human embryonic stem cells or human induced pluripotent stem cells, by direct reprogramming and induction of cardiomyocyte proliferation are discussed regarding their therapeutic potential and respective advantages and disadvantages.

Whether beta cells are obtained by direct reprogramming or from other sources, such as directed differentiation of pluripotent stem cells [ 41], it will be necessary to carefully characterize the phenotype of the cells before proceeding.

In 2007, induced pluripotent stem (iPS) cells were established from adult human fibroblasts by direct reprogramming with defined factors [8].

Pluripotency is a developmental ground state that can be recreated by direct reprogramming.

analyzed early transcriptional changes mediated by Neurog2 and Ascl1 during direct reprogramming of murine postnatal astrocytes into distinct neuronal subtypes in vitro.

Tissue-engineered 3-dimensional (3D) microenvironment enhances the direct reprogramming of fibroblasts into cardiomyocytes by microRNAs.