Sentence examples for by direct repression of from inspiring English sources

Here, by studying the reprogramming of mouse fibroblasts to neurons, we found that the pan neuron-specific transcription factor Myt1-like (Myt1l) exerts its pro-neuronal function by direct repression of many different somatic lineage programs except the neuronal program.

In RMS, deregulated PRC2 activity leads to constitutive expression of TBX2 which functions to drive proliferation by direct repression of CDKN1A, CDKN2A, and PTEN while inhibiting the activity of MYOD1 and MYOG27.

Glucocorticoid negative feedback of the hypothalamus-pituitary-adrenal axis is mediated in part by direct repression of gene transcription in glucocorticoid receptor (GR) expressing cells.

More specifically, ligand-activated ERα suppressed expression of slug by direct repression of transcription.

Our results imply that AP4 suppresses senescence by direct repression of p16 and p21.

AP4 achieves this effect by direct repression of p16 and p21, and may thereby critically contribute to c-MYC function and tumor progression.

This miR-92 effect is, at least in part, mediated by its direct repression of Fbw7, which promotes the proteosomal degradation of c-Myc.

hbox12 -dependent suppression of nodal gene expression in these cells is mediated by the transient inactivation of p38 and/or probably by direct repression.

In a tumor engraftment model, upregulation of the cluster by Myc in colonocytes increased tumorigenesis by promoting angiogenesis through direct repression of TSP-1 and CTGF by miR-18a and miR-19, respectively.

Direct repression of megakaryopoiesis by IFN-α by inhibiting TPO-induced signaling was demonstrated in one in vitro study [ 31].

RESULTS: MiR-33 extends the function of its host SREBP-2 by reducing biliary secretion through direct repression of ABCB11 and ATP8B1.