Sentence examples for by direct physical interaction from inspiring English sources

Although these effects could be driven by direct physical interaction with mitochondrial proteins and enzymes, this study supports an indirect interaction of GNPs with mitochondria, triggered by whole cell chemical processes such as oxidative stress.

Simultaneous induction of HIF and OS-9, however, strongly argues against activation of HIF hydroxylases by direct physical interaction with OS-9.

Astrocytes modulate the establishment and maintenance of synaptic contacts through the release of soluble factors such as cholesterol [19] or thrombospondins [20], or by direct physical interaction with neuronal cells [10] [13], [21].

Based on these facts, we propose that the inhibition of the PKCε activity, and hence the suppression of the SMMC-7721 hepatoma cell growth, was achieved though the formation of a complex by direct physical interaction between C/EBPβ 3'UTR RNA, PKCε and CK18.

Thus, knowledge of TFBS helps to identify potential target genes regulated by direct physical interaction with a transcription factor.

Aberrant entry into the mitotic phase has been shown to be due to down-regulation of p53 caused by direct physical interaction with PBK [ 65].

RNA immunoprecipitation assays demonstrated that some of these effects were mediated by direct physical interactions between Igf2bp3 and mRNAs that control proliferative activity and mesenchymal traits.

XIAP inhibits caspases, including caspase-3 and caspase-9, by direct physical interactions [ 46].

There is now a general consensus that the interaction between Patched1 and Smoothened is mediated by a small molecule (or molecules) that is regulated by Patched1, rather than by direct physical interactions between the two (Taipale et al., 2002).

While the reason behind the decrease in COQ5 levels is unclear, the decrease in COQ7 levels is justified by the direct physical interaction of COQ9 COQ7, which is needed by COQ9 to expose demethoxyubiquinone, the substrate for the reaction catalyzed by COQ7 (Garcia-Corzo et al, 2013; Lohman et al, 2014).

However, the membrane association of CD97 was preserved and only disappeared in cells with a totally disorganized cytoskeleton (fig. 5c) suggesting that CD97 is not likely to couple to F-actin by a direct physical interaction.