Sentence examples for by direct modulation of from inspiring English sources
Taken together, these observations led to the direct coupling hypothesis, whereby β modulates α1 gating by direct modulation of IS6 movement [8], [15].
Moreover, ERα signaling regulates estrogen production by direct modulation of the CYP19A1 promoter[30].
Utilizing a well-characterized experimental rat cardiac transplantation model, we have shown that allograft viability can be prolonged by direct modulation of host immunity via adoptive T cell therapy using rapamycin-generated Th2-type cells.
Moreover, a very recent analysis of the Frydman lab showed that polyQ aggregation kinetics is not solely a function of polyQ repeat length, but rather includes the critical contribution of the N-terminal 17 amino acid residues forming an amphipathic helix and promoting rapid Htt aggregation by direct modulation of Htt conformation [22].
In addition, by direct modulation of the pulmonary vasomotoric tone, GCs diminish pulmonary vasoconstriction and inhibit fibrogenesis [ 24, 34].
In addition, there is also experimental evidence suggesting complement activation can also induce fibrosis by direct modulation of fibroblast function.
The intensities of both LD's were sinusoidally modulated by direct modulation.
In yet another study, CYP CYP interaction was found to affect enzymatic function by a direct modulation of allosteric (non-Michaelis Menten) enon-Michaelis Menten
JNKs activate apoptotic signaling by upregulation of the pro-apoptotic genes through the transactivation of specific transcription factors or by a direct modulation of the activities of mitochondrial pro- and antiapoptotic proteins through distinct phosphorylation events (Dhanasekaran and Reddy, 2008).
Thus, the increased level of Ras/MAPK signaling conferred by NDK-1 might reflect direct modulation of KSR activity by NDK-1.
A role for leptin in inflammation is supported by reports of its direct modulation of monocyte, macrophage and T cell signalling and function [11], [12], [13].
