Sentence examples for by direct modification of from inspiring English sources

RONS may also activate CaMKKβ by direct modification of RONS sensitive motifs and, indirectly, by activating the ryanodine receptor (Ryr) to release Ca2+.

Increased O-GlcNAcylation has been implicated in the development of insulin resistance increasing adipocyte lipid metabolism by direct modification of IRS1 [53] and AMPK [19] respectively; however, such results have been under conditions of sustained increases in HBP flux and O-GlcNAcylation.

These results indicate that in addition to the stimulatory effect observed in intact cells (see Fig. 6A,D), H2O2 suppressed Kir6.2/SUR2A channel function in the cell-free condition, possibly by direct modification of the channel or some closely associated regulatory protein(s).

It is also possible that Jak signaling makes a contribution independently of Stat3 by direct modification of chromatin (Dawson et al., 2009).

These effects were linked to NO effects on outward-rectifying K+ channels which are Ca2+ insensitive, possibly by direct modification of the K+ channel by NO (Sokolovski and Blatt 2004).

This can be done by direct modification of electroactive surfaces by nanomaterials or by advanced patterning protocol and by using nanomaterials as amplification tags, helping to produce lectin biosensors/biochips working in an ultrasensitive and selective way.

This is possible by a direct modification of the subchannels' frequency-domain shapes, as shown in Figure 9.

Studies on ADAM8 and other metalloproteinases revealed that metalloproteinase activity alone can promote cell attachment, cell outgrowth and cell migration [36], [37], [38], [39], [40] by either direct modification of ECM components such as fibronectin [36], or from proteolytic release of cell adhesion molecules that indirectly modify cell attachment and migration [37], [38], [39], [40].

Because we were studying recombinant RyR2 expressed in HEK293 cells, the observed effects are caused solely by a direct modification of the channel protein itself.

Caspase involvement in cell death is suggested also by the higher IC50 for MCF-7 cells (Table 2)—cells that are known to be caspase-3-deficient.[ 31] In this report we describe the synthesis of the new glycyrrhetinic acid derivative methyl 2-cyano-3,12-dioxo-18βH-olean-9(11),1(2 -dien-30-oate (12 -dien-30-oate the direct modification of the A and C rings of glycyrrhetinic acid.

Although NO can inhibit caspase-1 activity by direct modification, we asked whether the inhibitory effect of NO on ASC pyroptosome formation was caspase-1 independent.