Sentence examples for by direct interaction and from inspiring English sources
Our data would predict that at least some of these LRR domains confer resistance to bacterial (and other microorganisms) infection by direct interaction and termination of the pathogen.
Dysbindin co-immunoprecipitated with GASP-1 (or GPRASP-1), a cytoplasmic protein shown previously to modulate lysosomal trafficking of D2 dopamine and delta opioid receptors by direct interaction, and with HRS that is a core component of the conserved ESCRT machinery mediating lysosome biogenesis and sorting.
In this study, NS1 was shown to prevent oligomerization of TRIM25 by direct interaction and therefore prevent the ability of TRIM25 to ubiquitinate and activate RIG-I.
The BCL-2 family proteins, BCL-2, BCL-XL and MCL-1 block autophagy by direct interaction and inhibition of BECN1.
We demonstrated that TP53INP1 impacts on p53 and p73 transcriptional activity by direct interaction and mediates the antioxidant activity of p53 (Tomasini et al, 2003, 2005; Cano et al, 2009).
The Teschke-group results represent a clear, complete story of mutant instability, chaperone rescue by direct interaction, and phenotypic buffering that has a direct impact on fitness (in this case, of the phage).
Here, we show that FF-based derivatives arrest parasite growth by direct interaction with and inhibition of the protein translation enzyme prolyl-tRNA synthetase (PRS).
They are thought to regulate expression of protein-coding genes by direct interaction with and degradation of mRNA or by inhibition of protein translation [ 64].
PAK1 has been reported to regulate the ERK pathway by direct interaction between PAK1 and Raf and MEK.
According to this model, pro-apoptotic BH3-only proteins activate Bak and Bax only by neutralizing pro-survival proteins such as Bcl-2, and not by direct interaction between Bak/Bax and the BH3-only proteins.
Taken together, the studies described here indicate that PARP-1 and PARylation inhibit rRNA synthesis and maintain silent rDNA chromatin by direct interaction with pRNA and the chromatin-remodeling complex NoRC, causing epigenomic reprogramming during cell division.
