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These probabilities were projected to districts by direct extrapolation.
Furthermore, the first studies reporting TUBB gene mutations were made in hamster cells [ 11] and in ovarian cancer cell lines [ 10] after selection by paclitaxel exposure, something that makes difficult a direct extrapolation of these findings to human tumours.
However, direct extrapolation of these results to tissue levels experienced by the retina of patients has not been possible.
The question that rises is whether this can be simply explained by the differences between neonatal and adult respiratory failure and whether these differences preclude direct extrapolation of the neonatal data to adults.
Direct extrapolation of our data predicts that Tph1 mice would be more prone to develop PAH in response to hypoxia than WT mice.
Direct extrapolation of the study results to other Trusts, or even other specialties, is not possible.
A direct extrapolation of this assumption is that the increased brain size could be achieved by an increased efficiency of factors involved in cell cycle progression, mitosis, or by preventing apoptosis.
The single-centre design of this study precludes the direct extrapolation of these results to the wide spectrum of ICUs.
Firstly, its observational cross-sectional design precludes the inference of causality relationships and direct extrapolation of associations.
However, differences in clinical manifestation among Asian patients with PsA have been described [ 16], which limit direct extrapolation of results.
Direct extrapolation of the data to the in vivo parotid gland function must be done with some precaution.
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