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The modules having the composition reported in Table 1 were prepared by direct compression using a 19 × 8 mm punch set (Fellc compressing model F-10/8, São Paulo, Brazil).
The new drug delivery system is obtained, at room temperature, by direct compression using conventional pharmaceutical equipment.
The tablets were prepared by direct compression using nano-coated microcrystalline cellulose Avicel PH105 as a tablet binder, which provided both excellent tabletability and good flowability.
The study was aimed at developing extended release matrix tablets of poorly water-soluble diclofenac sodium and highly water-soluble metformin hydrochloride by direct compression using cashew gum, xanthan gum and hydroxypropylmethylcellulose (HPMC) as release retardants.
Then, tablets were prepared by direct compression using a single-punch tablet press (Specac Ltd., Kent, United Kingdom).
To accomplish the goal stated above, bilayer tablets composed of an atenolol sustained-release layer combined with atorvastatin fast-release layer were manufactured by direct compression using conventional tabletting facilities in a simple and easy-to-scale-up formulation strategy.
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The approach is verified by designing a new pharmaceutical formulation for direct compression, using an API that was previously formulated via a wet granulated process.
The unidirectional buccal tablets of Mirtazapine were prepared by direct compression method using Carbopol 934P and HPMC K4M as a buccoadhesive controlled release agents.
Vancomycin HCl sustained release tablets were prepared by direct compression technique using guar gum as the main matrix forming materials in different concentrations: 20, 30, 40, 50, and 60% w/w of tablet (300 mg).
The results obtained confirm that the SeDeM Method is an appropriate system, effective tool for determining a viable formulation for tablets prepared by direct compression, and can thus be used as the basis for the relevant pharmaceutical development.
Tablets containing caffeine anhydrate were prepared by direct compression at various compression force levels using different shaped punches.
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