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Together with the fact that hTIM-3 only enhanced EBOV entry very inefficiently (Kondratowicz et al., 2011; Moller-Tank et al., 2013), these indicate that the efficiency of viral entry via interaction of TIM proteins with PS of the viral membrane is low when compared to the one mediated by direct binding between hTIM-1 and GP.
Altogether, these data suggest that the aPKC PAR complex interacts with the nephrin podocin complex by direct binding between the PDZ domains of PAR3 and two cytoplasmic regions of nephrin, including the CT11 and ICD-A regions.
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Therefore, Ssa2p is the first factor that assists tRNA import by direct binding to tRNAs, shuttles between the cytosol and the nucleus, interacts with the NPC component, and couples the tRNA transport with energy release.
AS2O3-induced degradation of PML-RARA is initiated by the direct binding between AS2O3 and PML-RARA (Jeanne et al., 2010).
In humans this interaction is mediated by a direct binding between eIF4G and three eIF3 subunits (eIF3c, eIF3d and eIF3e) [ 70] whilst in yeast this is done indirectly, through eIF5 [ 71].
Type XIV collagen has recently been identified as a binding partner of COMP in vitro (Agarwal et al., 2012), which suggests the possibility that a disruption to the ECM by Matn3 V194D and Comp DelD469 mutations could affect type XIV collagen stability in the ECM by altering direct binding between these proteins.
Each of the peptides was tested whether it binds to MPO by direct binding ELISA.
IRF4 controls transcription of the Blimp-1 gene prdm1 by direct binding to a conserved noncoding sequence between exons 5 and 6 (Sciammas et al, 2006).
CaEs may also functionally protect AChE from insecticide toxicity by direct binding and sequestration, thereby preventing or delaying interaction between the insecticide and AChE (Jokanovic 2001; Maxwell 1992a).
The non-catalytic inhibitors inactivate SFKs by direct binding.
All bacteria used prevented VSV binding to the cell monolayers by direct binding of VSV to their surface.
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