Sentence examples for by direct activation of from inspiring English sources
A number of snake venom serine proteinases with thrombin-like activity showed procoagulant activity " in vitro" by direct activation of factor V [ 37– 39], factor VIII [ 28, 40], and factor X [ 41].
Pretreatment of cells with forskolin, that activates protein kinase-A by direct activation of adenylate cyclase, also caused adrenomedullin receptor desensitization.
One day after a preventive treatment with either anti-IL-23R mAb or an isotype control, autoimmune colitis was induced in Rag2−/− mice by direct activation of inflammatory dendritic cells and macrophages with a CD40 agonist that mimics activated T cells (Supplementary Figure S1).
Bhattacharyya, S. et al. Enveloped viruses disable innate immune responses in dendritic cells by direct activation of TAM receptors.
Caloca, M.J., Zugaza, J.L., Matallanas, D., Crespo, P. & Bustelo, X.R. Vav mediates Ras stimulation by direct activation of the GDP/GTP exchange factor Ras GRP1.
Furthermore, another study points out that the pro-nociceptive effect could possibly be due to the release of 5-HT acting on 5-HT3 –receptors or even by direct activation of the 5-HT3 –receptors [31].
GPCRs have long been regarded as on/off-switches, which is reflected by direct activation or blockade of these receptors through the majority of marketed GPCR drugs.
These results imply that motor preparation is contaminated both by the direct activation of number magnitude and by the congruity between the spatial location of a target number and its magnitude.
They deliver pro-apoptotic signals at the plasma membrane by formation of a DISC and by subsequent direct activation of a proteolytic caspase signaling cascade in so-called 'type I' cells or via an additional (intrinsic) mitochondrial amplification loop in 'type II' cells.
Neurogenic pain is caused by the direct activation of nociceptive nerve terminals, whereas inflammatory pain is mediated by a combination of peripheral input and spinal cord sensitization.
Bacterial infection induces apoptosis which is frequently mediated by the direct activation of caspases in the absence of death receptor ligation.
