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Subtle sequence variants can arise from homologous miRNA loci or by differential processing of the product of a single miRNA locus, which are then called isomiRs (11).
In the future, keeping track of correct miRNA annotation is speculated to become even more challenging owing to the discovery of isomiRs (11), subtle sequence variants arising by differential processing of precursor and mature miRNAs depending on tissue type, developmental stage and physiological conditions.
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We believe that they could be explained either by the differential processing of the primary transcript or by the differential affinity of the probes to their respective mature miRNA.
Multiple isozymes are produced by tissue-specific differential processing of PKLR mRNA.
This disparity in the activation of Rafs may play a critical role in the differential processing of signals generated by IL-1β and mechanical forces.
Thus, our results substantiate the hypothesis [ 22] that elicitation leads to over-production of the CanPI precursors and enhanced, differential processing of the precursors by proteases to IRDs, resulting in structurally and functionally diverse processed products.
On the other hand, photographic stimuli as used in our previous study may not be so easily reducible to abstract basic elements, engaging resources in processing the stimulus category even in color identification and thus showing the effects of differential processing of phobic stimuli by spider phobics.
Interestingly, studying the differential processing of the spliced peptides by the proteasome, Dalet et al. observed that three spliced peptides were better produced by the standard proteasome, while one peptide was better produced by the immunoproteasome [ 151].
Moreover, the population of short sequence reads produced allows the identification of differential processing of stem-loop precursors by DICER-LIKE1, and mature miRNA isoforms within and between species.
The method based on differential processing of GC-MS data was originally proposed by Ghosh and Anderegg [ 39, 40], and subsequently developed further by Pool and co-authors [ 41, 42].
Differential processing of word meaning in the absence of explicit memory was most likely responsible for differential electrical and behavioral responses to old versus new words.
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