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Such methods are underpinned by different statistical approaches, so each method could provide different clustering/cluster results for the same set of data (Waller and Gotway 2004).
Our study produced three main novel findings which were consistently verified by different statistical approaches.
The few outlier loci and genomic regions identified in this study were not supported by different statistical approaches.
By different statistical approaches, we finally provide evidence of the lack of dependence between changes at the transcriptome and translatome levels.
Modules consist of groups of biomolecules (genes, proteins, or gene products in general) that are found (often by different statistical approaches) to regulate as a unit a biological property or phenotype.
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Our results support the role of miRNA expression patterns in MS. The reliability of the data is sustained by the different statistical approaches, by validation in an independent cohort of samples and by the congruent results, both in the gene ontology analysis and in the animal model analysis.
Our analyses found a consistent, significant increase in diabetes risk among those reporting antidepressant medication use by four different statistical approaches.
About one tenth (8.5%) of patients who had ever received chemotherapy were still receiving chemotherapy within 14 days of death; this population experienced no survival benefit as determined by three different statistical approaches.
The suitability of candidate control genes was evaluated by applying three different statistical approaches to expression data (i.e. Ct values).
In an effort to ensure the accuracy of the reference gene stability ranking and minimize bias introduced by the validation approach, four different statistical approaches, ∆Ct, geNorm, NormFinder, and BestKeeper, were used to identify the suitable reference genes for accurate normalization in this study.
The risk of such an event is minimized by the use of 3 different statistical approaches that search for associations through different procedures.
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CEO of Professional Science Editing for Scientists @ prosciediting.com