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Even with the same experimental data, the accuracies of the identification by different methods can be significantly different.
Deletion of the LRP6 extracellular domain potently activates signaling in a Wnt-independent manner, and forced extracellular dimerization of this recombinant protein by different methods can either enhance or inhibit this activity [18], [19].
Plots of the distributions of ECs for all human-mouse orthologous gene pairs and 4040 human-mouse random gene pairs, generated by different methods can be found in Figure 1.
Furthermore, curcuminoids solubilized in sera by different methods can be combined to achieve optimal curcuminoid ratios for specific treatment regiments or cell culture applications.
Blocking or obstructing the VEGF/VEGFR signal transduction pathway by different methods can prevent the vascularization, metastasis, and edema of animal transplanted tumors and result in restricted tumor growth [ 25, 26].
Noted, the pathways identified by different methods can be significantly observed in the analysis on the replicated dataset (P-value less than 0.05, whose details are supplied in Additional file 7: Table S7).
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Raw correlations measured by the different methods can be compared on two criteria: whether they agree in sign (positive, zero, or negative); and whether they agree in magnitude.
The recall and precision rates obtained by the different methods can, however, give a rough estimate of the relative performance.
The data sets acquired by the three different methods can principally be considered independent, because we used data collected using different detectors, and we did not select identical cell regions to extract donor/acceptor signal or emission spectra data for any of the quantitative methods.
Polyphenol contents obtained by the five different methods can also be compared.
However, gene signatures defined by different investigators using different methods can be quite various even when applied on the same disease and the same endpoint.
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