The availability of DREADDs activated by different ligands provides enhanced opportunities for investigating diverse physiological systems using multiplexed chemogenetic actuators.
Previous studies compared different ER ligands using reporter constructs with different ERE sequences [30], [31].
It can be potentially used to predict how signaling pathways are affected by different ligands and how this response is altered by diseases.
Thus, cripto controls the differential use of (or access to) the activin receptor by different ligands.
In conclusion, microbubbles functionalized by different ligands can be labeled with radiotracers and utilized for SPECT/CT imaging, while the incorporation of SPION in MB shells enables imaging using MR. Our investigation revealed that biodistribution may be modified using different ligands.
The functionalization of MBs by different ligands to incorporate superparamagnetic iron oxide nanoparticles (SPION) makes them visible by multimodality imaging techniques, thus enabling their use for diagnostic purposes [9].
The results suggest that the Slo3 channel is gated by different ligands in different species.
Differential positioning of receptors by different ligands may also influence signaling qualitatively [ 67*, 68, 69*].
β2-Integrins exist in three conformational states characterized by different ligand binding affinities.
This may be explained by the different TLR-2 ligands used or be due to the different protocols used for the establishment of tolDCs.
