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It is therefore possible that the multiple functions of our candidates are actually carried out by different isoforms of the same gene.
The same NL1-expressing cells, however, did not form this higher-order architecture with cells expressing the much longer neurexin-1 α isoform, suggesting a functional discrimination mechanism between synaptic contacts made by different isoforms of neurexin variants.
From these protein families, it was observed that the most abundant was the lipocalin family, specifically represented by different isoforms of Lopap (a prothrombin activator protein), reinforcing its relevance during envenoming.
Nitric oxide (NO), a hydrophobic gaseous molecule, is synthesised from L-arginine by different isoforms of nitric oxide synthase (NOS).
Therefore, the change in lipid metabolism mediated by different isoforms of apoE could influence the neuronal degenerative processes.
It is produced as a free radical by different isoforms of the enzyme nitric oxide synthase (NOS).
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Transgene expression in Drosophila is affected by positional effects on transgene activity which complicate comparisons of the toxicity mediated by different isoforms or mutant forms of human Tau.
The initial modification reaction involves removal of acetyl groups from GlcNAc residues, followed by sulfation of the amino group catalyzed by four different isoforms of N-deacetylase/N-sulfotransferases [ 4, 16], a reaction essential for the creation of sulfated S-domains.
Moreover, a growing bulk of experimental evidence points to oxysterols as potential inducers of reactive oxygen species (ROS), either by inducing different isoforms of the NADPH oxidase, or by deranging the mitochondrial membrane potential (Pedruzzi et al., 2004; Biasi et al., 2009; Gamba et al., 2011; Biasi et al., 2013).
As the polymer forms, the first reaction involved in polymer modification involves removal of acetyl groups from GlcNAc residues, followed by sulfation of the amino group which is catalyzed by four different isoforms of N-deacetylase/N-sulfotransferases [ 13].
As the chain polymerizes, it undergoes a series of modifications; the initial modification reactions involve removal of acetyl groups from GlcNAc residues, followed by sulfation of the amino group which is catalyzed by four different isoforms of N-deacetylase/N-sulfotransferases: NDST1-4 [ 13, 14].
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