By comparing the different experimental systems and conditions among us four groups, we think the different results are understandable.
However, in this manuscript we show data consistent with previously published data 16, 21, 24, 38 and with our hypothesis that Hh can attenuate the DP to SP transition, by using many different experimental systems.
The reasons for such disparate results are currently unknown, but may relate to the use of different experimental systems and/or to putative differences in self-antigen processing by lymph node stromal cells and dendritic cells.
Geminin's role in controlling the extent of DNA replication has been well documented by many different laboratories using many different experimental systems [11], [27].
Another point raised by DeFelice and Cameron is that the difference in decay kinetics observed between these different experimental systems (HEK-293 cells and oocytes) could be due to the presence of the patch electrode in HEK-293 cells.
It is likely that the differences in results are due to different experimental systems or cells.
It remains to be established whether such a discrepancy reflects differences in the mismatched discrimination mechanism employed by two polymerases, or whether it results from different experimental systems and conditions.
Similarly, the innate responses mediated by NOD2, in response to MTB-derived antigens, vary in different experimental systems.
In order to fine tune the analysis to the specific characteristics of different experimental systems, all of the parameters can be adjusted by the user via dialogue windows (Additional file 2 and Additional file 3).
Two different polymers are treated by two different ions, e.g., argon and oxygen in two different laboratories demonstrating that the concept of long pulse, high frequency PIII can be converted to different polymers and different experimental systems.
