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This discrepancy might be explained by differences between the different cell models employed (mouse vs. human) and by different experimental settings.
We performed the unsupervised meta-analysis on absolute fold changes to reduce variation introduced by different experimental settings.
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This difference could be explained by the different experimental settings such as the virulence of bacterial strain tested, bacterial culture conditions and assay medium as previously reported for other human pathogens (Tan et al., 1999; Garsin et al., 2001; Lee et al., 2011).
The discrepancy might be explained by the different experimental settings and cell systems that were used in previous studies.
We note that some of the challenges in the supervised model construction and evaluation posed by the different experimental settings have been stated before.
Table 8 shows the percentage of individuals pruned by TEAM under different experimental settings.
This difference may be due to genuine pharmacodynamic characteristics of the tested drugs, but could also be caused by the completely different experimental settings.
The accumulated data represent a remarkable substrate for the analysis of global molecular changes invoked by kidney IRI in different experimental settings.
Although some of the discrepancies could be caused by the use of different experimental settings and reagents, we speculated that CLU exerts pleiotropic effects in cancer that could be strictly context dependent.
Powerful fitting procedures are required to calibrate model parameters in the context of several experimental datasets, often under different experimental settings and with different sets of measured species.
HN is also effective against cell death caused by non-AD-related insults under different experimental settings, such as serum depriviation, prion peptide118-135, IGFBP3 (insulinsulin-liketh factor binding protein 3), staurosporine etc. [8], [9], [10], [11].
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