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However, Sherman et al. reported that the degree of coronary collateral formation was not determined by differences in systemic levels of angiogenic factors [ 43].
Another possible explanation for the discordant treatment responses is that the intraindividual discordance in UAE and SBP response is accounted for by differences in systemic and local RAAS activity or differences in the extent of tissue penetration of RAAS blockade.
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It appears that the difference in brain Hg exposure between thimerosal and MeHg is largely driven by their differences in systemic disposition kinetics (i.e., the blood level).
Given that the largest differences in survival were found for women with metastatic disease, we would expect this to be largely driven by differences in the use of systemic therapies (Koscielny et al, 2009).
Results are, therefore, exclusively dependent on the uptake kinetics in the studied tissue and are not affected by inter- and intra-individual differences in systemic FDG disposition.
However, differences in systemic treatment persisted after adjustment for stage.
Many variables may contribute to differences in systemic inflammation.
(5) The constraints imposed by external equivalence fix the values of the altered parameters in such a way that arbitrary differences in systemic behavior are eliminated.
Differences in systemic host immune responses were monitored in serum of infected animals.
There were no consistent differences in systemic adverse events between ranibizumab and laser or placebo.
Notably, we did not find any significant differences in systemic blood pressure among the 2 groups.
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