The scenarios above are further complicated by differences in the regulation of Perforin-2 in different cells.
It is not known whether this seeming discrepancy can be explained by differences between PP5 and its yeast homologue Ppt1, or by differences in GR regulation between yeast and mammalian cells in general.
The reason for this discrepancy is unclear, but it may be explained by differences in HDAC5 regulation between bovine aortic endothelial cells as used by Ha et al. [ 11] and HUVECs used in the present study.
Our results support the hypothesis that virulence at low temperatures is explained primarily by differences in temperature dependent regulation of proteins present in all the strains.
It is likely, though, that 'flavour phenotype' variation amongst wine yeast strains will be determined by differences in transcriptional network regulation.
To explain this sexual dimorphism, it has been hypothesized that the differential susceptibility to complex diseases, such as obesity and diabetes, in men and women is mediated by differences in the epigenetic regulation of genes induced by sex hormones (22).
However, it is possible that target genes of PCN vary between tissues, because of differences in available partners for dimerization, dominant negative LITTLE-ZIPPERs [53], [54], different co-factors, or differences in regulation by miRNA165/166 in different tissues.
From the above analyses, we can see that qualitative differences in regulation by growth-rate between different nutrient environments are quite rare.
Differences in recommendations are often explainable by differences in the structure and regulation of health care systems and, therefore, different premises and goals.
