However, we recognize the need to take into account the rock type dependency of the ESR signal intensity caused by differences in radionuclide activity in different rocks.
Differences in radionuclide uptake between approaches (Trochanteric flip and Posterior) were displayed graphically using box and whisker plots and formally tested using Mann-Whitney tests, with significance set at the 5% level.
There was no statistically significant difference in radionuclide uptake between the posterior approach group and the trochanteric flip approach group in the head/neck region (ROI 1) (p = 0.724, Mann-Whitney test).
This could in part be explained by the profound differences in dose rate; dose rate effects on the transcriptional response have previously been described in vivo following radionuclide administration [22, 25, 29].
The differences in dose-response for the radionuclides can be explained by the differences in dose (in a 1-g tumour: Y 46 Gy, In 3 × 14 Gy, and Lu 64 Gy).
The differences in half-life between the radionuclides we used required the inclusion of both early and late evaluation time points (1, 4 and 24 h p.i).
In the present study using internal radionuclide exposure, differences in differential expression between time points were influenced not only by, e.g., the biological response time of certain regulatory events but also by continuous irradiation and increased absorbed dose over respective periods.
Among soils, variation in radionuclide activies may be due to differences in carbonate content, organic matter and/or grain size.
We believe that differences from the butterfly dynamics may be because of differences in generation time, ecological status, amount and species of radionuclides released, and other factors.
The major difference in both production methods are the used concentrations of precursor, radionuclide production of [18F]F2 and the differences in SA of FDOPA.
