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Contrasting results compared to published RCTs may be explained by differences in dose and duration of colloid infusion.
31 Differences in risk estimates attributed to use of hormone treatment may therefore be caused by differences in dose or drug properties between preparations.
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As shown by Brookes and colleagues [ 39], the discrepancy between these two studies may be explained by differences in doses.
Within study variance could be explained in part by differences in doses, with higher adverse event rates generally reported among higher doses (Ritchie et al 2004).
This difference may at least in part be explained by differences in doses, patient cohorts, and organ pathology, as a relationship between renal and hepatic function for liver transplantations has been described.
Lack of attenuation of insulin-induced weight gain by metformin has been observed in other studies (8), although these analyses may have been confounded by differences in doses of insulin used between those using or not using metformin.
Findings from supplement studies with micronutrients such as chromium, magnesium, and vitamin D are conflicting and confounded by differences in dosing, micronutrient levels achieved with supplementation, baseline micronutrient status, and/or methodologies used.
Differences in gene expression results between these in vitro studies may be explained by differences in As dose because the effects of As are highly dose dependent.
Little et al. (2010) pointed out that in epidemiological studies of cancer and ionizing radiation, statistical power is influenced much more by differences in mean dose than by the number of cases.
Although dosing of propofol could be affected by differences in opioid doses, it has been reported to not affect the relation between propofol concentrations and BIS [ 27].
46 The discordant findings observed between the different trials may be partly explained by differences in the doses of fatty acids tested or the interval between the initial event and the start of the supplementation.
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