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This method could be affected by differences in dataset size between species, i.e. small P-values in one species may lead to subsequent small P-values in the cross-species combined distribution, as was detected for the non-normalized data (data not shown).
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Since the assessment of the heterogeneity among estimated index values may be affected by differences in number of polymorphic sites among datasets, we adopted the approach of Schaeffer [ 62] to account for possible bias.
Translating signatures to a new dataset is complicated by differences in microarray platforms and data processing procedures, as well as the clinical differences between cohorts.
Inevitably, the compilation of various datasets, collected by different researchers, includes a high degree of heterogeneity, partly generated by differences in temporal and spatial scales of sampling.
Sometimes, lack of fit may be caused by differences in the definition, measurement or even units of variables between the two datasets.
The inability of most existing datasets to generate signatures capable of distinguishing between tumor vascular subtypes may be partially explained by differences in the isolation technique used.
This could mean that the siRNA concentrations employed to derive most of the entries in SIR are similar to those in the other datasets, or that the feature selection process is not significantly affected by difference in concentrations amongst datasets, or both.
A direct comparison between the models produced in this work and other models predicting Vss reported in the literature is complicated by the differences in the datasets and types of regression methods used.
As is shown in the Figure 4A-1 and 4B-1, the differences between resultant and distributive features in hydroxylysine dataset are similar to the differences in hydroxyproline dataset.
Dunn's Multiple Comparison Test was used for global differences in the dataset followed by a posthoc test for selected pairs (p* < 0.05; **p < 0.01; ***p < 0.001).
We performed cluster analyses to explore differences in our dataset.
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