However, the analysis provides a baseline for the within-country dimension of the monitoring and evaluation of the KT platforms located in these countries (with cross-country comparisons limited by likely differences in database coverage).
However, database meta-analysis is complicated by differences in experimental technologies, data post-processing, database formats, and inconsistent gene and sample annotation.
The database content statistics of the five databases (Table 2) already show that there are notable differences in database size.
When translating between databases, inherent differences in database structure, syntax and search algorithms need to be understood for optimal retrieval.
Our findings highlight the role played by differences in curation policies (past or present) across databases.
The higher number of peptides identified by the MTC database was expected to be caused by differences in the interpretation of coding sequences.
In the case of this study, we speculate that the general trend of lower nausea rates in the PLM database compared to those reported in corresponding medication labels is driven largely by differences in data collection mechanisms.
These observations can be explained by taking a closer look at the differences in the databases and their spoofing attack scenarios.
In each case the results were sorted on percent identity rather than e-value since the latter value can be biased by random differences in the length of database sequences.
In favor of a direct role for estrogen in sex differences in substrate utilization, database searches reveal that MCAD, SCHAD, PPARα, PPARδ, and PPARγ have up-stream estrogen response elements (ERE) [63] suggesting these genes may be regulated by estrogen.
