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Between countries, such variations may be exacerbated by differences in coding systems and contrasting components of the healthcare systems which may affect how morbidity data is recorded and collected.
This is not explained by differences in coding region length (Supplementary Material, Figs S1 and S2).
Some of these differences may be caused by the under-reporting of diagnostic variables, others by differences in coding approaches.
They were, however not able to determine, whether this increase at least in part could be explained by differences in coding during the study period.
The use of secondary data is limited by the threat of validity posed by inaccurate data within healthcare information technology systems as well as by differences in coding and documentation practices at the provider, region, or site-specific level.
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Structural divergence between duplicated genes was measured by differences in coding-region lengths and average exon lengths, and the number of indels and maximum indel length in their protein sequence alignment.
In Arabidopsis thaliana, we denote levels of structural divergence between duplicated genes by differences in coding-region lengths and average exon lengths, and the number of insertions/deletions (indels) and maximum indel length in their protein sequence alignment.
When measured by differences in coding-region lengths and average exon lengths and the maximum indel length, structural divergence between duplicated genes shows the following trend: WGD < tandem < proximal < transposed (comparisons between consecutive gene duplication modes are significant at α = 0.05, Wilcoxon test).
To ensure reliability of coding and interpretation, a sample of data fragments were checked and resolved through dialogue with other members of the team by one researcher (AP) identifying differences in coding between the five coders and speaking with the coders in question to arrive at an agreement.
Analysis will be conducted by two independent researchers using a constant comparative method [ 69], with any differences in coding resolved by discussion.
We employed established methods for solving differences in coding qualitative research by reconciling such discrepancies through group discussions and consensus [ 16].
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