Sentence examples for by differences in cellular from inspiring English sources
Potential advantages of a direct rescue approach are that expression of proteins involved in other metabolic pathways would not be altered and rescue would be less affected by differences in cellular folding environments in different tissues or in different disease states.
Application of this technology for studying gene expression profiles from bronchial biopsy samples may also be limited by differences in cellular composition due to differing proportions of epithelial cells, fibroblasts, and smooth muscle cells that may occur in asthmatic and control tissue as a result of biopsy techniques.
Despite the consistency of the trends described above, the different fitness of nanocomplex candidates could only be partially explained by differences in cellular uptake, endosomal escape, and rate of nanocomplex dissociation.
Therefore, the differences observed in the selectivity of transfection between cancer and normal cell lines is probably not controlled by differences in cellular entry, and the intracellular barriers to transfection in this system are likely to be endosomal escape or nuclear entry, as investigated in Part II, the companion paper to this work.
Mitochondrial number can be affected by differences in cellular proliferation or passage numbers of the clones.
However, one major challenge is to distinguish true epigenetic variation from changes caused by differences in cellular composition between the disease and non-disease state, a problem that is particularly relevant when analyzing whole blood.
In order to exclude that reduced VEGF-A expression levels in PBMC from SPMS patients could be explained by difference in cellular composition, absolute and relative peripheral blood monocyte numbers were determined as part of a complete peripheral blood count in RRMS (n = 53), SPMS (n = 19) and controls (n = 58).
From studies of the proportions of different types of PrPd accumulation (the PrPd profile), we have proposed that the pathology phenotype of sheep strains are partly the result of differences in the relative affinity of different sheep scrapie agents for different cell types and by differences in the cellular processing of PrPd(15).
Differences between our data and those reported by Zhang and collaborators showing that CFTR localizes with some LAMP1 positive vesicles in freshly isolated lung macrophages might be explained either by differences in the cellular localization of CFTR in distinct species or in cells from different anatomical sites (periphery vs lung), or both.
They are characterized by variable expression in cells and tissues, which is influenced by differences in the cellular stage and stress.
In the present study, the promoter activity was not regulated by IFN-γ in FLSs (data not shown); however, this discrepancy could be explained by differences in the cellular properties of macrophages and FLSs.
