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The significant superiority of the cyclic form (PT3) compared to the open form (PT5) of pyridoxyl-tryptophan in inhibiting proliferation of the parasite can be explained by differences in binding of PfODC as indicated by the molecular modeling studies.
To determine whether the difference in the activity of LF-HMA and LF-A is caused by differences in binding affinity, we measured the apparent affinities (Kd) of LF-HMA and LF-A for protective antigen (PA).
Probe sets presumably affected by differences in binding efficiencies were removed.
37 This finding may potentially be explained by differences in binding ability, antigen presentation or functional capabilities.
These contributions were cancelled out by differences in binding energy contributions of amino acid residues 131 (Phe/Val) and 135 (Val/Leu), which were lower in CAIX by 0.7 and 0.9 kcal/mol, respectively.
The seemingly more pronounced inhibitory effect of citrate on the generation of C5a compared with C3a might be explained by differences in binding of the two anaphylatoxins for their respective receptors.
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Interestingly, virus progeny accumulation was not affected by differences in virus binding.
As proposed in the mouse study [19], an increased effect of insulin detemir in the brain may be explained by differences in albumin binding.
Switching expression of var genes is often accompanied by differences in the binding phenotype, allowing the parasite to escape the host's immune response.
We propose that these fundamental differences in evolutionary and epidemiological dynamics are driven by differences in hemagglutinin binding preferences.
The difference in aggregation between the two metals appears to be caused by differences in metal protein binding sites.
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