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While this complementary meta-analysis is of interest, it may be explained by differences between studies and/or by chance.
The findings of the review are limited by differences between studies including study design, clinical populations and patient selection, small sample sizes and non-standardized sample processing.
Challenges included: tensions within households and communities resulting from lack of clarity and agreement on who is eligible for benefits; suspicion regarding motivation for their provision; and confusion caused by differences between studies in types and levels of benefits.
It also seems likely that relatively little risk is attributable to individual genes, and that these small effect sizes are easily obscured by differences between studies and methodologies used.
Cross-trial comparisons with other abacavir-switch studies regarding lipid changes are limited by differences between studies in prevalence and severity of hyperlipidemia prior to the switch, specific PIs administered, pre-existing CAD risk factors of the particular patients enrolled, and stipulated dietary and exercise restrictions.
Comparison of the prevalence of preventive care found in this study with that previously reported is constrained by differences between studies in the definition of preventive care [ 34, 42], the behavioral risks addressed [ 34, 42, 43], data collection methods [ 34- 43], and the type of client [ 35, 41- 43].
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Higher long-term PM2.5, PM10, and NOx concentrations between study sites were associated with greater percent emphysema, though these findings were driven by differences between study sites and were not replicated for within-site exposure contrasts.
The discrepant results could perhaps be explained by differences between the studies in the assessment of insulin sensitivity or that our study sample consisted exclusively of elderly men.
Moreover, the divergent finding of the present investigation may also be explained by differences between the studies in the clinical characteristics and the age group investigated.
The divergent outcomes may have been influenced by differences between the studies, including variations in the amounts of GLP-2 delivered, the methods used to evaluate gastric emptying, and the content of test meals administered [ 21, 28- 30].
The difficulty to reproduce eQTL (and other genetic associations) is partly explained by differences between the study populations: different populations have different genetic backgrounds, which may considerably alter the phenotypes associated with a given allele.
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