Because there appeared to be a relationship between expression of ER α and decreased sensitivity of the cells' antiproliferation response to Acrp30, we chose to further investigate the interaction of Acrp30 and ER α by developing a new cell line designated MDA-ER α7.
As the most relevant mechanism of drug resistance developed by these cell lines is the overexpression of ABCB1 (Serra et al, 1993; Hattinger et al, 2009), additional experiments were performed in order to verify whether this membrane transporter may also mediate resistance against these two drugs.
Those who have come forward say they have developed stem cell lines that avoid the patent.
When asked by a reporter what the institutes would do, if and when scientists proved that the method worked and needed to develop new cell lines, Dr. Battey said, "When we come to that bridge, we will jump off it".
XX developed the cell lines.
The detection of EGFR mutations by SABER was developed from cell line and validated in lung cancer xenograph model and clinical sample.
Several investigators suggested that MGPs less biased by phenotype may be developed from cell line models.
With a DIPG tumor sample from a rapid autopsy, Raabe's team developed a cell line used by researchers in a dozen labs across three different continents to identify drugs that might work against the disease.
7 Based on these molecular and phenotypic observations, the aim of the present study was to recapitulate and translate the VDRE-BP-induced vitamin D-resistant state in human bone cells by developing and characterizing murine osteoblastic cell lines which stably over express tetrameric HNRNPC proteins.
To better understand the molecular basis of SDIA, in the current study we compared gene expression array data sets developed by profiling different cell lines, including the potent PA6 line, to identify genes potentially responsible for early DA induction of hESC.
