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Ultimately, the validity of our model will have to be tested by determining the structures of RadA-DNA nucleoprotein filaments, or by visualizing ATP-fueled axial rotation of RecA family protein filaments during homology pairing and strand exchange reactions through single molecule studies.
Bai et al. demonstrate the potential of direct-electron detectors in cryo-EM by determining the structures of two ribosomes.
The assessment of air contamination by asbestos, for health safety purposes, is carried out by determining the structures with a specific length-to-diameter ratio, and a length over 5 μm.
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The importance of the crystallographic interface between the TCP domain and the STIL peptide has been verified by mutagenesis and by determining the structure of the equivalent complex from Drosophila, revealing strong structural conservation despite weak sequence similarity.
Genes exert their effect mainly by determining the structure and function of the many thousands of different proteins, which in turn determine the characteristics of an organism.
The aim of this study was to explore the potential properties of natural silk for dental applications by determining the structure and features that make natural silk a biocompatible candidate.
They demonstrate this by determining the structure of the 80S ribosome with a resolution of close to 4 Angstroms.
Here, we have explored the issue further by determining the structure of the calcium-free (apo) C-terminal domain of F1 TnC (F1 CTnC) and studying its dynamics in solution.
Here we report our investigation on the evolution of the AZFc region of the Y chromosome by determining the structure and copy number of the DAZ gene and the conservation of AZFc ampliconic sequences on primate Y chromosomes.
By determining the structure of Pf80S in both a liganded and unliganded state, we were able to locate the binding site of the anti-protozoan inhibitor, emetine, using an unbiased difference map.
We verified this prediction by determining the structure of a fusion protein with the first nine ANK repeats of AnkB fused at the C-terminus of Nav1.2_ABD-C at 2.5 Å resolution.
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