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MPE and BY designed the study, AB and YS provided the metabolite measurements, BY analyzed data.
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TM-Y contributed by designing the study, in acquisition of data, and critical revision of the manuscript.
PEG, DJH, and DAH contributed equally to this work by designing the study and analysing the data.
SM and KH participated in the implementation of the project by designing the study protocols, collecting data, analyzing the results, and developing the diary.
By designing the study with adequate power for this association, we ensured sufficient power for all the other objectives that require substantially less power.
These problems can be overcome by sourcing animals from large herds and by designing the study prior to the birth of the study animals, which may be several years prior to the collection of phenotypes.
By designing the study to include analyses of response, locoregional control and progression-free survival, it may also be possible to generate hypotheses about the potential interactions between the IMP and radiation.
We planned these analyses in advance by designing the study to follow subjects during two seasonal phases and in different regions, known factors leading to differences in pollutant components and particle size distribution.
YLG, JDT, BY and XSC designed the study and wrote the initial manuscript.
AH came up with the idea of this study inspired by KTJ, designed the study, made all analyses and wrote the first draft of the manuscript.
JG and HR designed the study supported by SA.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com