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Allosteric ribozymes (aptazymes) that have extraordinary activation parameters have been generated in vitro by design and selection.
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By rational design and selection of biomaterials, we incorporated multiple functional moieties in each layer compartment.
It is shown that some of these new materials display interesting photoluminescent properties, which may be fine-tuned by careful host molecular design and selection of an appropriate lanthanide ion, and have potential for application in devices, particularly as sensors.
This approach to studying peptide recognition can be applied to other domains and to a variety of structural and functional models by tailoring the combinatorial library design and selection pressures accordingly.
We have attempted to deal with these limitations in the original research by designing and applying rather stringent selection criteria so that our results are based on solid coherent evidence.
An existing estimation distribution algorithm (EDA) with univariate marginal Gaussian model was improved by designing and incorporating an extreme elitism selection method.
Of the DNA-binding motifs that have been manipulated by design or selection, Cys2-His2 zinc finger proteins have demonstrated the greatest potential for manipulation into general and specific transcription factors.
CAE is a key enabler to meet program timing and program cost by design selection right the first time before hardware and prototypes are available.
The applications of bionic methodology developed by the Laboratory of Design and Material Selection as basis in the creation of junction elements were demonstrated.
PCR primers specific for the chiA gene were designed by alignment and selection of highly conserved regions of chiA sequences from Serratia marcescens, Alteromonas sp., Bacillus circulans and Aeromonas caviae.
In our study, the estimated genetic correlation differed in degree as well as direction across different LGs, suggesting some possibility of breaking this undesirable correlation by means of carefully designed breeding and selection strategies, but further work on elucidating the genetic architecture of WCI and IB is required first.
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