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Further, this work defines the role of the DAT in the addictive potential of AMPHs by demonstrating that increased DAT expression robustly augments the effects of AMPH-like drugs on dopamine neurotransmission.
We have partially explained this paradox by demonstrating that increased bio-availability of IL-2 upon daclizumab treatment predicted by mechanistic in-vitro studies 28 activates CD56bright NK cells 19, 28 and common ILC precursors 18 expressing high levels of intermediate affinity IL-2R unhindered by daclizumab.
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However, egg laying by these females was reduced by approximately 30% (Fig. 4E), demonstrating that increased dFOXO activity specifically within the germline is sufficient to reduce egg production.
Further, the mutants of CIITA, which produced the highest level of Gag-Pol, did not demonstrate a linear increase in Gag processing or virion infectivity, which may be explained by previous work demonstrateing that increased Gag-Pol levels impairs viral infectivity [61], [62].
We previously demonstrated the validity of this method with OAI images by demonstrating that increases in BML volume were associated with cartilage loss, and BML volumes differed across Boston Leeds Osteoarthritis Knee Score [ 18].
We have previously reported the construct validity of this method with OAI images by demonstrating that increases in BML volume were associated with cartilage loss and BML volumes differed across the Boston Leeds Osteoarthritis Knee Score [ 21].
This investigation has confirmed that an APP response occurs in sheep experimentally-infected with C. pseudotuberculosis, and extends the previous report of an increase in the concentration of serum Hp in CLA [ 9] by demonstrating that increases also occur in the concentrations of SAA and AGP.
The findings of the present study contribute to furthering understanding of the respiratory health effects associated with specific components of PM2.5 by demonstrating that increases in respiratory morbidity are associated with acute increases in BC, an indicator of DEPs, but not with PM2.5 as a whole.
We obtained further evidence of enhancement of cellular ibandronate accumulation by calcium by demonstrating that high calcium levels increased the inhibition of protein prenylation induced by the bisphosphonate.
Recently, an elegant study by Iizuka et al (2000) supported a possibility by demonstrating that reduced nm23 expression could increase cisplatin resistance.
By demonstrating that pathogenic prions trigger increases in A-beta levels through the deviation of PrPC signaling, our data argue that A-beta may exacerbate prion-induced toxicity.
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