The principal relevance of NKG2D signaling for the outcome of allogeneic HSCT is further emphasized by studies demonstrating an effect of the genotype of the NKG2D ligand RAET1L (Antoun et al, 2012) and NKG2D (Espinoza et al, 2009) itself on overall survival of patients.
By increasing the statistical power for demonstrating an effect of IPP/VPP in reducing BP, our meta-analysis provides convincing evidence of such an effect, whereas individual studies failed to do so.
Collectively, these results emphasize the vulnerability of Z. marina to habitat fragmentation by demonstrating a negative effect on seed density and an impact on seed distribution, which likely reduces the potential advantages of sexual reproduction for bed growth and resiliency to perturbations.
Our study adds to this by demonstrating a lasting effect of prior disadvantage in food competition on adult foraging behaviour and energy reserves.
This systematic review and meta-analysis utilising all available clinical trials fills an important gap of certainty in the current evidence by demonstrating a beneficial effect in the use of taxane for unfavourable CUP patients.
Thus, our findings complete these observations by demonstrating a direct effect of dasatinib on osteoblasts, which could further contribute to the disruption of the vicious circle established between bone cells and tumor cells.
In certain instances (especially in trials of amyloid-based therapies), including EOAD subjects and inherently the autosomal dominant subset may increase power by demonstrating a larger effect in the genotype-specific cases as compared with the multifactorial sporadic cases.
Our work adds new knowledge to the field by demonstrating an observable treatment effect in a larger cohort of participants, in a study that was appropriately double blinded and placebo controlled.
7 8 The follow-up design adopted in this study eliminated the cohort effect and health selection by demonstrating a true age effect.
