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The identification of OA meQTLs greatly assists our interpretation of OA susceptibility by demonstrating a functional link between genetics and epigenetics for this common, age-related disease.
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The mutant phenotype was rescued by subfamily 1 receptors but not by subfamily 2 receptors, demonstrating a functional difference between the receptor subfamilies, one possibility being their difference in kinase activity.
Interestingly, when comparing the migratory activity of cells treated with SFM or Ang II, we demonstrate that both direct treatment and a concentration gradient of Ang II significantly increased the chemokinetic migration of cells by ∼75% (Figure 3B) demonstrating a functional measure of myoblast activation.
VDAC2 cells resist the mitochondrial dysfunction and apoptosis caused by global O-GlcNAc perturbation, demonstrating a functional connection between O-GlcNAc signaling and mitochondrial physiology through VDAC2.
Connectivity analyses extended these findings by demonstrating a task-dependent functional circuit between dmPFC and ventral and dorsal portions of premotor cortex.
Connectivity analyses extended our findings by demonstrating a task-dependent functional circuit between 1) dmPFC and left PMv, 2) left pre-SMA and right PMv, and 3) between vermis VIII in the cerebellum and right M1.
This study adds to the body of knowledge by demonstrating a statistical association between functional every day tasks and more global measures of health status.
Suppression of recombinant HCN2 single-channel activity by KCR1 clearly demonstrated a functional effect of KCR1 on HCN channel behavior.
Our study however, provides evidence of direct uptake of a miR from human BCM by HEEC and demonstrates a functional effect on adhesion.
In line with a direct role of LUATs, several examples have demonstrated a functional regulation by mammalian antisense transcripts in cis[ 11, 62, 63].
This is in agreement with recent work by Iwama et al. [24], who demonstrated a functional interaction of AHK5 with the ethylene and ABA response in the control of root growth in Arabidopsis.
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