Tumour initiation can be prevented by deletion of the Sox2 gene.
Epistatic analysis revealed that ISG activation could not be overcome by deletion of canonical RNA sensors.
Derepression of glucose metabolism by deletion of the regulatory gene sugR and avoiding l-lactate formation by deletion of the lactate dehydrogenase gene ldhA increased ectoine productivity.
The RepliVax® vaccine (RV) platform is based on flavivirus genomes that are rationally attenuated by deletion.
The glycerol production pathway was impaired by deletion of the genes FPS1 and GPD2.
Reduction of thalamic and cortical Ih by deletion of TRIP8b produces a mouse model of human absence epilepsy.
In this study, we investigated integration effects of enhancing valine biosynthesis by overexpression of ILV2 and BAT2 with eliminating ethanol formation by deletion of PDC6 and decreasing acetyl-CoA biosynthesis by deletion of LPD1 on isobutanol titers.
An atypical N-terminal appendix runs across one β-sheet and thereby stabilizes the domain as shown by deletion experiments.
To achieve this, the shikimate pathway was blocked by deletion of shikimate kinases and quinic acid/shikimate dehydrogenase.
By deletion of this motif or a single point mutation (INW390A), BET-independent MLV (BinMLV) were engineered.
Spinal muscular atrophy is a monogenic, progressive motor neuron disorder caused by deletion or mutation in the SMN1 gene.
