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This leads to an ambiguity in defining the margin.
Tumour response evaluation by RECIST may also be limited by problems in defining the margins of ill-defined or irregular lesions and in some instances it is not possible to measure sites of disease involvement, e.g. bone marrow disease (Fig. 1).
Taking a largely empirical approach this paper addresses the global spread of new technologies by defining two diffusion margins – the extensive, referring to the spreading of first use across economies and the intensive, referring to the intensity of use within economies.
This may be achieved in two main ways: by improving imaging used in defining the prostate volume, and by reducing the margins used during radiotherapy treatment planning.
In view of the current results, it is interesting to note that the estimated carcinogenic hazard of methyleugenol (defined by the margin between the daily human intake and the lowest dose that induced a specific tumor in an animal model) is about 25-fold and 100-fold greater than the hazards of benzo[ a]pyrene and PhIP, respectively.
A region of interest (ROI) is defined by the margins of the tumor, and several enhancement parameters are measured (Fig. 1).
It is bounded circumferentially by the mesorectal fascia, which defines the potential circumferential resection margin in patients undergoing TME.
VOI of the sacrum was defined by the bone margin from the start to end of the sacrum on each transaxial CT images.
Internally, the borders of the menisci were defined by the internal margin of the cartilage surface of MT and LT, because these are continuous with the transverse and menisco-femoral ligament and because no intrinsic anatomical demarcation could be used to separate these structures.
The superior aspect of the ventricular complex is defined by the superior margin of the arytenoids cartilages (Fig. 1a).
The integrity of the graft material as demonstrated by the linear and defined margin of the contrast-medium inside the stent-graft needs to be observed (arrows).
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