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The SAGE data can be mined to find genes with analogous profiles by defining expression patterns representative of the COR and CBF genes.
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Koning, F.A. et al. Defining APOBEC3 expression patterns in human tissues and hematopoietic cell subsets.
Affymetrix U133A expression data was used to define gene expression patterns by mutation, type of mutation, and cancer stage.
Since previous studies have demonstrated a good resemblance of subgroups defined by common tumor markers to molecular subtypes defined by mRNA expression patterns [ 13, 14], we used cytosolic protein levels of ER and PgR and used TMA immunostaining of HER2, CK5/14 and EGFR to classify the material into five tumor subgroups.
As a first step toward advancing our understanding of ERK dynamics in complex tissues, we have defined gene expression patterns regulated by ERK oscillations and provide an initial assessment of regulatory nodes that may mediate oscillation-specific gene expression that are also targets of stress-responsive signaling.
Given the three distinctive subgroups of mouse HCC models, we sought to examine how well these models recapitulate human HCC phenotypes as defined by gene expression patterns.
Perou et al. (2000) reported evidence for breast cancer tumor subtypes defined by gene expression patterns.
The groups defined by gene expression patterns were in some cases paralleled by the location of the primary tumors.
Moreover, a maximal e-CCC-Bicluster can be defined by several expression patterns (see Figure 5 and Figure 6).
The differences between lineage-committed cells and the pluripotent cells from which they originated are largely defined by gene expression patterns.
Self-organizing cluster analysis revealed five cluster groups defined by the expression patterns of the 14 genes in the 136 GISTs (Fig. 2, Tables 1 and S2).
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