Sentence examples for by defective activation of from inspiring English sources

Additionally, MEF2C depletion was accompanied by defective activation of S6K in response to pressure overload.

Additionally, the results of the current study reveal that the anti-hypertrophic effects of MEF2C depletion may be related to a defective mobilization of mTOR/S6K by pressure overload, which may be associated with an intricate mechanism that involves negative modulation of the mtDNA replication and changes in myocardial energy metabolism caused by defective activation of PGC-1α.

The data indicate that depletion of MEF2C is sufficient to markedly attenuate the hypertrophic growth and myocardial fibrosis of overloaded left ventricle by a mechanism dependent on defective activation of mTOR/S6K pathway.

Rosiglitazone, Insulin Treatment, and Fasting Correct Defective Activation of Protein Kinase C- /? by Insulin in Vastus Lateralis MusC- / and Adipocytes of DiabytInsulin.

If the mechanism used by IL-6 to reduce food intake is AMPK-dependent, as our results suggest, the defective activation of AMPK in the hypothalamic neurons induced by exercise may increase the ability of leptin to reduce food intake.

Cells lacking macroH2A1 have defective recruitment of 53BP1, defective activation of chk2 kinase and increased radiosensitivity.

Human neutrophil dysfunction with giant granules and defective activation of the respiratory burst.

CAPRI-deficient macrophages had impaired FcgammaR-mediated phagocytosis and oxidative burst, as well as defective activation of Cdc42 and Rac1.

Knockdown of DDX41 via short hairpin RNA inhibited immune response to c-di-GMP and resulted in defective activation of the STING-TBK1-IRF3 pathway.

Thus, we reasoned that supplementation with leucine might rescue the defective activation of mTOR/S6K complex after depletion of MEF2C.

They also suggest that defective activation of NF-κB could lead to an M2 phenotype.