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Poisoning causes fetal tissue hypoxia by decreasing the release of maternal oxygen to the fetus.
FOXO/4E-BP overexpression in muscles regulates organism-wide protein homeostasis by reducing feeding and also by decreasing the release of insulin-like growth factors from neurosecretory cells in the brain [ 195].
Although additional mechanisms are involved in mediating the angiogenic effects of COX-2, our data imply that COX-2 inhibitors influence angiogenesis at least in part by decreasing the release of VEGF.
In previous studies, we analyzed a series of labdane diterpenes, some of them showing potent anti-inflammatory activity by decreasing the release of inflammatory mediators (NO, PGE2, cytokines) through inhibition of NF- κB activity.
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We showed how river regulation by dams does not affect the sign of the trends, but its magnitude, by decreasing the releases during winter to meet the demand of water in summer creating important seasonal differences.
The metabotropic glutamate receptor 3 (GRM3), a member of the group II family of mGlus, is coupled to second message pathways via GTP-binding proteins and is involved in presynaptic depression by decreasing the evoked release of glutamate [ 11].
Indeed, patch-clamp recordings revealed that DMI pretreatment completely normalized the increase of the sEPSC amplitude and the strong decrease in synaptic facilitation induced by FS-stress, suggesting that the antidepressant counteracts the effect of stress on glutamate release by decreasing the probability of release.
This effect would be expected to increase appetite by decreasing the likelihood of release of the anorectic peptide α-MSH.
Presynaptically they regulate transmission, e.g. by decreasing the probability of transmitter release.
Persistent nociceptive stimulation caused by inflammation and/or neuropathy can affect neurotransmission at this level in three ways: 1) by decreasing the number of sites that release GABA and glycine; 2) by decreasing the number of receptors to which they bind; and 3) by increasing the speed by which the inhibitory neurotransmitters are removed from the synaptic cleft [67, 68].
Persistent nociceptive stimulation caused by inflammation and/or neuropathy can affect neurotransmission at this level in three ways: 1) by decreasing the number of sites that release GABA and glycine; 2) by decreasing the number of receptors to which they bind; and 3) by increasing the speed by which the inhibitory neurotransmitters are removed from the synaptic cleft [ 67, 68].
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by decreasing the content
by decreasing the likelihood
by decreasing the surface
by decreasing the length
by decreasing the risk
by decreasing the grain
by decreasing the cell
by decreasing the level
by decreasing the affinity
by decreasing the free
by decreasing the dose
by decreasing the contact
by reducing the release
by decreasing the proportion
by decreasing the plasma
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com