Sentence examples for by decreasing the binding from inspiring English sources
Unfortunately, metronomic S-1 dosing resulted in impaired delivery of PEG-coated "cationic" liposomes into tumor tissue, presumably by decreasing the binding sites on tumor blood vessels available for the liposomes.
Our results establish that in the background of Q151Mc, K70Q causes TFV resistance through a third mechanism: by decreasing the binding affinity of the inhibitor (Kd-dependent exclusion mechanism).
NO modulates leukocyte adhesion in the microcirculation by decreasing the binding of PMN to the adhesion molecules E-selectin and ICAM-1 [ 22, 24].
Furthermore, the antioxidant activity of AND might protect LDL against copper mediated modification, by decreasing the binding of Cu2+ to LDL.
On the other hand, at a concentration of 25 μM, BITC decreased cyclin D1 expression independently of p65 possibly by decreasing the binding of β-catenin to the TBE0 site by downregulating the expression of nuclear β-catenin.
In keeping with this, some strains of H. pylori may have evolved to either inactivate apo-Fur regulation of sodB, or to weaken repression by decreasing the Fur/sodB binding affinity.
Instead, our results indicate that the thiazolidinediones blocked AI-2 QS in V. harveyi by decreasing the DNA-binding ability of LuxR.
Cinnamaldehyde has previously been shown to inhibit QS-regulated virulence by decreasing the DNA-binding ability of the QS response regulator LuxR.
It was previously shown that cinnamaldehyde inhibits AI-2 QS by decreasing the DNA-binding ability of LuxR to its promoter DNA [10].
Cinnamaldehyde is known to affect AI-2 QS [10], [11] and we have previously shown that cinnamaldehyde disrupts QS-regulated virulence in Vibrio spp. by decreasing the DNA-binding activity of the response regulator LuxR [10].
Meanwhile, we have preliminarily deciphered the potential molecular mechanisms of EEDL, namely, inhibiting the LPS-induced iNOS/NO, COX-2/PGE2 and cytokines levels by decreasing the DNA-binding activity of NF-κB p65.
