Thus, NEP transcription initiation may avert detrimental effects of point mutations by decreasing specificity.
Given the danger of misidentifying a cancer patient (which could lead to death), tests are generally designed to ensure a high sensitivity by decreasing specificity (i.e. increasing false positives to ensure that as many positives are identified).
However, this increased sensitivity is accompanied by decreased specificity.
Overdosing with reactants decreases specificity of treatments by increasing the number of affected oxidants and diminishing survival rates [ 6, 7].
By applying MTV-corrected cutoff values of T/N ratio (1.23), diagnostic performance could be maintained without decreasing specificity in small-sized lesions (Table 2).
Three factors influenced specificity: inclusion of NTBR patients decreased specificity; studies of good quality or high prevalence (≥ 15%) showed higher specificity.
One can argue that E-selectin decreases specificity by increasing the number of the bound cells that are not targeted, e.g. binding of other PSA-negative cells such as MCF-7 cells and leukocytes on the aPSA stripes.
The inhibition of cholinesterases by alkyl isocyanates shows a pattern of decreased specificity with decreased alkyl chain length.
To evaluate to what extent an increase in sensitivity by double FIT sampling went at the cost of decreased specificity, single FIT and the three double FIT strategies were analyzed at equal specificities.
However, these optical techniques often are limited by small fields of view (microscopy), decreased specificity due to autofluorescence, or rapid photobleaching.
